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Facile and efficient synthesis of quinoline-4-carboxylic acids under microwave irradiation |
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| Authors: | Hui Zhu Ri Fang Yang Liu Hong Yun Jin Li |
| Affiliation: | Beijing Institute of Pharmacology and Toxicology, Department of Medicinal Chemistry, Beijing 100850, China |
| Abstract: | A facile and efficient method for the preparation of 2-non-substituted quinoline-4-carboxylic acids is described via the Pfitzinger reaction of isatins with sodium pyruvate following consequent decarboxylation under microwave irradiation. |
| Keywords: | Quinoline-4-carboxylic acids Pfitzinger reaction Microwave irradiation |
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