| Interaction of Hypocrellin B or Mono-cysteine Substituted Hypocrellin B with CT-DNA by Spectral Methods |
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| 引用本文： | JiaHongZHOU ShengQinXIA XueSongWANG BaoWenZHANG YiCAO. Interaction of Hypocrellin B or Mono-cysteine Substituted Hypocrellin B with CT-DNA by Spectral Methods[J]. 中国化学快报, 2003, 14(10): 1054-1057 |
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| 作者姓名： | JiaHongZHOU ShengQinXIA XueSongWANG BaoWenZHANG YiCAO |
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| 作者单位： | TechnicalInstituteofPhysicsandChemistry,ChineseAcademyofSciences,Beijing100101 |
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| 摘 要： | The interaction of the anticancer drug hypocrellin B (FIB) or the mono-cysteine substituted hypocrellin B (MCHB) and calf thymus deoxyribonucleic acid (CT-DNA) has been investigated using spectral methods. The results of UV-visible spectra show that the HB and MCHB could intercalate into the base-stacking domain of the CT-DNA double helix. The studies of fluorescence spectra and circular dichroism(CD) spectra also support the interacalation mechanism.
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| 关 键 词： | 交互作用机理 HypocrellinB 单半胱氨酸 取代 CT-DNA 光谱分析 HIV-1 获得性免疫缺陷综合症病毒 疱疹性口炎病毒 抗病毒药 |
Interaction of Hypocrellin B or Mono-cysteine Substituted Hypocrellin B with CT-DNA by Spectral Methods |
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| Jia Hong ZHOU,Sheng Qin XIA,Xue Song WANG,Bao Wen ZHANG,Yi CAO. Interaction of Hypocrellin B or Mono-cysteine Substituted Hypocrellin B with CT-DNA by Spectral Methods[J]. Chinese Chemical Letters, 2003, 14(10): 1054-1057 |
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| Authors: | Jia Hong ZHOU Sheng Qin XIA Xue Song WANG Bao Wen ZHANG Yi CAO |
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| Abstract: | The interaction of the anticancer drug hypocrellin B (HB) or the mono-cysteine substituted hypocrellin B (MCHB) and calf thymus deoxyribonucleic acid (CT-DNA) has been investigated using spectral methods. The results of UV-visible spectra show that the HB and MCHB could intercalate into the base-stacking domain of the CT-DNA double helix. The studies of fluorescence spectra and circular dichroism(CD) spectra also support the interacalation mechanism. |
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| Keywords: | Hypocrellin B mono-cysteine substituted hypocrellin B CT-DNA interacalation mechanism. |
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