A concise total synthesis of (-)-maoecrystal Z |
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| Authors: | Cha Jacob Y Yeoman John T S Reisman Sarah E |
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| Institution: | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States. |
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| Abstract: | The first total synthesis of (-)-maoecrystal Z is described. The key steps of the synthesis include a diastereoselective Ti(III)-mediated reductive epoxide coupling reaction and a diastereoselective Sm(II)-mediated reductive cascade cyclization reaction. These transformations enabled the preparation of (-)-maoecrystal Z in only 12 steps from (-)-γ-cyclogeraniol. |
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