Catalytic asymmetric synthesis of optically active allenes from terminal alkynes |
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| Authors: | Ye Juntao Li Suhua Chen Bo Fan Wu Kuang Jinqiang Liu Jinxian Liu Yu Miao Bukeyan Wan Baoqiang Wang Yuli Xie Xi Yu Qiong Yuan Weiming Ma Shengming |
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| Affiliation: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, PR China. |
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| Abstract: | CuBr and ZnI(2) have been developed as catalysts or subcatalysts for the efficient asymmetric synthesis of axially chiral allenols with up to 97% ee from readily available propargylic alcohols, aliphatic or aromatic aldehyde, pyrrolidine, and commerically available ligands. The alcohol unit in the terminal alkynes plays a very important role for ensuring high enantioselectivity via coordination. |
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