Synthesis of pyrido[1,2-a]indole malonates and amines through aryne annulation |
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Authors: | Rogness Donald C Markina Nataliya A Waldo Jesse P Larock Richard C |
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Institution: | Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. |
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Abstract: | Pyrido1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido1,2-a]indoles in moderate to good yields. |
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