Highly sensitive DNA hybridization detection with single nanoparticle flash-lamp darkfield microscopy |
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| Authors: | Yuan Zhiqin Cheng Jing Cheng Xiaodong He Yan Yeung Edward S |
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| Institution: | State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China. |
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| Abstract: | We developed a novel method for counting single gold nanoparticles in free solution with flash-lamp darkfield microscopy and demonstrated that it could be applied to highly sensitive DNA hybridization detection based on target DNA induced AuNP aggregation and counts reduction. |
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