Immobilization of aminothiols on poly(oxyethylene H‐phosphonate)s and poly(oxyethylene phosphate)s—An approach to polymeric protective agents for radiotherapy of cancer |
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| Authors: | Kolio Troev Ivelina Tsatcheva Neli Koseva Radostina Georgieva Ivan Gitsov |
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| Institution: | 1. Institute of Polymers, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria;2. Kolio Troev, Institute of Polymers, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria;3. Ivan Gitsov, Michael M. Szwarc Polymer Research Institute, State University of New York, Syracuse, New York 13210;4. National Center of Radiobiology and Radiation Protection, 132 Kl. Ohridski Boulevard, Sofia 1756, Bulgaria;5. Michael M. Szwarc Polymer Research Institute, State University of New York, Syracuse, New York 13210;6. Department of Chemistry, College of Environmental Science and Forestry, State University of New York, Syracuse, New York 13210 |
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| Abstract: | This study describes the synthesis and characterization of polymer complexes constructed from the radioprotective agent S‐2(3‐aminopropylamino) ethylphosphorothioic acid dihydrate (amifostine or WR‐2721), applied in the radiation cancer treatment, and biodegradable poly(oxyethylene H‐phosphonate), poly(hydroxyoxyethylene phosphate), or poly(methyloxyethylene phosphate). The immobilization of another radioprotector, used in cancer radiotherapy, 1‐(3‐aminopropyl)aminoethanethiol (WR‐1065) on the same polymers is also achieved through a covalent bond (Atherton‐Todd reaction coupling), ionic bond, and physical complexation, respectively. The structure of the complexes formed is elucidated by 1H‐ 13C‐, 31P NMR and FTIR spectroscopy. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1349–1363, 2007 |
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| Keywords: | biodegradable drug delivery systems poly(phosphonates) radioprotectors water‐soluble polymers |
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