Preparation of porous biodegradable microspheres with direct melting dispersion method |
| |
| Authors: | Yoshinari Taguchi Hiroshi Yokoyama Makiko Hara Masato Tanaka |
| |
| Institution: | 1. Department of Chemistry and Chemical Engineering, Niigata University, 8050, Ikarashi 2‐nocho, Niigata‐shi, Niigata 950‐2181, Japan;2. Department of Chemistry and Chemical Engineering, Niigata University, 8050, Ikarashi 2‐nocho, Niigata‐shi, Niigata 950‐2181, JapanDepartment of Chemistry and Chemical Engineering, Niigata University, 8050, Ikarashi 2‐nocho, Niigata‐shi, Niigata 950‐2181, Japan. |
| |
| Abstract: | Porous biodegradable microspheres can be prepared by using the direct melting dispersion method without any noxious organic solvents, in which the biodegradable polymer is directly melted and stirred to form the liquid–liquid dispersion followed by cooling in the continuous phase, such as ethylene glycol with the higher melting temperature than polymer. In the experiment, polyhydroxybutyrate (PHB) was adopted as the biodegradable polymer. As particulate porogen, magnetite powder was pre‐mixed into the melted polymer and removed by hydrochloric acid aqueous solution after preparation of the microspheres to make them porous. It was found that the inner surface area was significantly increased by removing magnetite powder. Copyright © 2007 John Wiley & Sons, Ltd. |
| |
| Keywords: | porous microspheres dispersions biodegradable polyhydroxybutyrate melt |
|
|
