Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production |
| |
| Authors: | Yan Yan Lihan Zhang Takuya Ito Xudong Qu Yoshinori Asakawa Takayoshi Awakawa Ikuro Abe Wen Liu |
| |
| Affiliation: | State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China, Graduate School of Pharmaceutical Science, University of Tokyo , 7-3-1 Hongo, Bunkyo-ku 113-0033, Japan, and Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Yamashiro-cho, Tokushima 770-8514, Japan. |
| |
| Abstract: | We herein report comparative analysis of two versions of the biosynthetic gene clusters of antimycins, a natural product family possessing up to 44 distinct entities. The biosynthetic pathway of antimycins is amenable to the high structural variation of the substrates, supported by successes in heterologous expression of the ant cluster and in fluorine incorporation. The latter facilitated the investigation of the structure-activity relationship into the usually invariable 3-formamidosalicylic acid moiety of the molecules. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
