Synthesis of pyrano[2,3-<Emphasis Type="Italic">c</Emphasis>]pyrazoles by ionic liquids under green and eco-safe conditions |
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| Authors: | Masoumeh Zakeri Mohamed Mahmoud Nasef Tina Kargaran Arshad Ahmad Ebrahim Abouzari-Lotf Jahanbakhsh Asadi |
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| Institution: | 1.Centre for Hydrogen Energy, Institute of Future Energy,Universiti Teknologi Malaysia,Kuala Lumpur,Malaysia;2.Malaysia-Japan International Institute of Technology, International Campus,Universiti Teknologi Malaysia,Kuala Lumpur,Malaysia;3.Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch,Islamic Azad University,Tehran,Iran;4.Metabolic Disordes Research Center,Golestan University of Medical Sciences,Gorgan,Iran |
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| Abstract: | Optimization of a green approach to the synthesis of pyrano2,3-c]pyrazoles based on the one-pot, four-component condensation via a domino Knoevenagel/Michael/cyclization sequence was investigated. This method involved the evaluation of the activity of several ionic liquids (ILs) in various solvents. This one-pot, four-component reaction revealed simplicity, higher yield and lower toxicity advantages over a corresponding three-component method. The effect of reaction parameters including the type and amount of catalyst, type of solvent, reaction temperature and time were studied with respect to yield of pyrano2,3-c]pyrazoles. Catalyst recyclability and time-saving aspects of the reaction suggest that this method presents real alternatives over conventional reaction protocols. |
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