Structural dynamics,phase behavior,and applications of polyelectrolyte complex micelles |
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| Institution: | 1. Department of Materials Science & Engineering, University of Central Florida, Orlando, FL, USA;2. NanoScience & Technology Center, University of Central Florida, Orlando, FL, USA;1. National Hellenic Research Foundation, Athens, Greece;2. National and Kapodistrian University of Athens, Athens, Greece;1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China;2. Ingénierie des Matériaux Polymères, UMR CNRS 5223, Université de Lyon, Université Claude Bernard Lyon 1, 15 Bd. André Latarjet, 69622, Villeurbanne Cedex, France;1. Institute for Complex Molecular Systems, Eindhoven University of Technology, Post Office Box 513, 5600 MD, Eindhoven, Netherlands;2. Laboratory of Macromolecular and Organic Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Post Office Box 513, 5600 MD, Eindhoven, Netherlands;3. Laboratory of Physical Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Post Office Box 513, 5600 MD, Eindhoven, Netherlands;1. Departamento de Química Física I, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain;2. Instituto Pluridisciplinar, Universidad Complutense de Madrid, Paseo Juan XXIII 1, 28040 Madrid, Spain;1. Department of Chemical Engineering, Aristotle University of Thessaloniki, P.O. Box 472, 54124 Thessaloniki, Greece;2. Chemical Process & Energy Resources Institute, Centre for Research and Technology Hellas, P.O. Box 60361, 57001 Thessaloniki, Greece |
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| Abstract: | Self-assembly between oppositely charged polyelectrolytes conjugated to neutral polymeric blocks form polyelectrolyte complex (PEC) micelles. These nanostructures have gained significant interest in the field of nucleic acid and protein delivery, along with emerging applications in biosensing and catalysis. These carriers are highly modular systems, with the ability to engineer stimuli-responsive and targeting properties, making them smart platforms for biomedical applications. In this review, we discuss the current understanding of mechanisms involved in the assembly and disassembly of these nanoparticles, and the structural and functional changes as a response to solution conditions. We also discuss the latest and most impactful applications of PEC micellar systems in the biomedical field, with far-reaching influence on the treatment of various human diseases. |
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| Keywords: | Self-assembly Polyelectrolytes Polyelectrolyte complex Micelles Coacervate Nanoparticles Drug delivery Nucleic acids Proteins Stimuli-responsive |
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