Harnessing the full potential of extracellular vesicles as drug carriers |
| |
| Institution: | 1. Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA;2. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA;3. Department of Biology, University of North Florida, Jacksonville, FL 32224, USA;4. Wenzhou Institute of Biomaterials and Engineering, Ningbo Institute of Industrial Technology, Chinese Academy of Sciences, Wenzhou, China;1. Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands;2. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands;3. Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada;4. Division of Cell Biology, Department of Biology, Utrecht University, Utrecht, The Netherlands;1. Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan;2. Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;3. Research Fellow of the Japan Society for the Promotion of Science (JSPS), Tokyo, Japan |
| |
| Abstract: | Extracellular vesicles are natural delivery systems widely implicated in cellular communication. However, to fully utilize these vehicles as nanocarriers, we must explore various methods to modify their applicability as drug delivery vehicles. In this review, we outline and discuss techniques to engineer extracellular vehicles for enhanced loading, targeting, circulation, and tracking. We highlight cutting-edge methods to amplify extracellular vesicle secretion and production and optimize storage conditions to improve their clinical suitability. Moreover, we focus on reverse engineering as an important step in controlling their biological function. By taking a reductionist approach to characterize and understand the individual components of these carriers, we can not only elucidate complex mechanisms of action but also advance the field through the creation of synthetic drug delivery vehicles. Finally, we propose current challenges and future directions of the field. |
| |
| Keywords: | Extracellular vesicles Cargo loading Reverse engineering Surface modification Storage Production Vaccine |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
