1,3-Oxazole derivatives of cytisine as potential inhibitors of glutathione reductase of Candida spp.: QSAR modeling,docking analysis and experimental study of new anti-Candida agents
Institution:
1. V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 02094, Kyiv-94, Murmanska Str,1, Kyiv, Ukraine;2. Nizhyn Mykola Gogol State University, 16600, Grafska Str. 2, Nizhyn, Chernihivska Oblast, Ukraine;3. P.L. Shupyk National Medical Academy of Postgraduate Education, 04112, Dorogozhytska Str, 9, Kyiv, Ukraine;1. V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Science of Ukraine, Kyiv, 02094, Ukraine;2. National University of Food Technologies, Kyiv, 01601, Ukraine;3. Department of Pharmaceutical Sciences College of Pharmacy, University of Kentucky, Lexington, KY 40536-0509, USA;4. Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0509, USA;1. Department of Genetic Engineering & Biotechnology, Shahjalal University of Science & Technology, Sylhet, 3114, Bangladesh;2. Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, 8440 112 St. NW, Edmonton, AB, T6G 2R7, Canada;1. Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH;2. Department of Biomedical Data Science, Geisel School of Medicine, Lebanon, NH;3. Department of Biological Sciences, Dartmouth College, Hanover, NH;4. Department of Epidemiology, Geisel School of Medicine, Lebanon, NH
Abstract:
Natural products as well as their derivatives play a significant role in the discovery of new biologically active compounds in the different areas of our life especially in the field of medicine. The synthesis of compounds produced from natural products including cytisine is one approach for the wider use of natural substances in the development of new drugs. QSAR modeling was used to predict and select of biologically active cytisine-containing 1,3-oxazoles. The eleven most promising compounds were identified, synthesized and tested. The activity of the synthesized compounds was evaluated using the disc diffusion method against C. albicans M 885 (ATCC 10,231) strain and clinical fluconazole-resistant Candida krusei strain. Molecular docking of the most active compounds as potential inhibitors of the Candida spp. glutathione reductase was performed using the AutoDock Vina. The built classification models demonstrated good stability, robustness and predictive power. The eleven cytisine-containing 1,3-oxazoles were synthesized and their activity against Candida spp. was evaluated. Compounds 10, 11 as potential inhibitors of the Candida spp. glutathione reductase demonstrated the high activity against C. albicans M 885 (ATCC 10,231) strain and clinical fluconazole-resistant Candida krusei strain. The studied compounds 10, 11 present the interesting scaffold for further investigation as potential inhibitors of the Candida spp. glutathione reductase with the promising antifungal properties. The developed models are publicly available online at http://ochem.eu/article/120720 and could be used by scientists for design of new more effective drugs.
