Synthesis and in vitro cytotoxic evaluation of new derivatives of pyrido[1,2-a]benzimidazolic ring system: the pyrido[1',2':1,2]imidazo[4,5-h]quinazolines |
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Authors: | Dupuy M Pinguet F Chavignon O Chezal J M Teulade J C Chapat J P Blache Y |
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Institution: | Laboratoire de Chimie organique Pharmaceutique, E.A. 2414, Faculté de Pharmacie, Montpellier, France. |
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Abstract: | Access to the original series of pyrido1',2':1,2]imidazo4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some "N-C-N" bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytotoxic activities against HL60 and A2780 cells. All compounds exhibited cytotoxic activities on resistant cell lines (MDR+; HL60R and A2780R) with no resistance phenomena. |
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