Structural, spectral and antimicrobial studies of copper(II) complexes of 2-benzoylpyridine N(4)-cyclohexyl thiosemicarbazone |
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Authors: | Marthakutty Joseph V Suni Maliyeckal R Prathapachandra Kurup Munirathinam Nethaji Archana Kishore Sarita G Bhat |
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Institution: | aDepartment of Applied Chemistry, Cochin University of Science and Technology, Kochi 682022, Kerala, India bDepartment of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India cDepartment of Biotechnology, Cochin University of Science and Technology, Kochi 682022, Kerala, India |
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Abstract: | Six new copper(II) complexes of 2-benzoylpyridine N(4)-cyclohexyl thiosemicarbazone (HL) have been synthesized and characterized by different physicochemical techniques like molar conductivity measurements, magnetic studies and electronic, infrared and EPR spectral studies. Five of the complexes have been found to possess the stoichiometry CuLX], where X = Cl (1), Br (2), NO3 (3), NCS (4), N3 (5). The complex prepared from copper sulfate has the composition Cu2L2SO4] · (H2O)2 (6). In all the complexes the deprotonated ligand, L and the anion were found to be coordinated to the Cu(II) ion. The terdentate nature of the ligand is evident from the IR spectra. The metal ligand bonding parameters evaluated from the EPR spectra indicate strong in-plane σ and in-plane π bonding. The magnetic and spectroscopic data indicate a square planar geometry for complexes 1, 3, 4 and 5, while the complexes 2 and 6 are assigned a square pyramidal geometry. Crystal structure of the complex CuLCl] reveals two molecules per asymmetric unit of a monoclinic lattice, with space group symmetry P21/n. The complexes CuLBr 2] (2) and CuLNCS] (4) crystallized into triclinic lattices with space group . Compound 2 exists as a thiolate bridged copper(II) dimer. The antimicrobial activity of the ligand and the copper complexes were tested against five types of bacteria isolated from clinical samples. The complexes were found to be active against Bacillus sp., Vibrio cholera O1, Staphylococcus aurus and Salmonella paratyphi. |
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Keywords: | Copper(II) complexes 2-Benzoylpyridine Thiosemicarbazone EPR Antimicrobial activity Crystal structure |
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