Continuous chromatographic separation process: simulated moving bed allowing simultaneous withdrawal of three fractions |
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Authors: | A. Navarro H. Caruel L. Rigal P. Phemius |
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Affiliation: | aLaboratoire de Chimie Agro-Industrielle, INPT, U.A. INRA 31A1010, Ecole Nationale Superieure de Chimie de Toulouse, 118 Route de Narbonne, 31077 Toulouse Cedex, France |
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Abstract: | Continuous counter-current chromatographic separation has been carried out in a simulated moving bed system (SMB). We have worked with a SMB pilot plant (8 columns, 4.4 litres of resin each) which allows the continuous withdrawal of two different fractions. A mixture of glucose-fructose has been separated. To calculate the concentration profile within the separator an axial dispersed plug flow model and an equilibrium stage model have been employed; software has been created to simulate the behaviour of the separator. The necessary parameters of the mode: the adsorption equilibrium constant, the height equivalent to a theoretical plate and the bed voidage, have been acquired experimentally from elution chromatography measurements. The results calculated by simulation give a good representation of the experimental concentration profiles; other separations like xylitol-arabitol have been simulated. The influence of some factors like desorbent flow-rate, feed flow-rate and the bed voidage have been studied using the software. Once the system has worked in a two withdrawal way, an extension of the pilot plant has been constructed so as to obtain a third one. The necessary parameters of the three withdrawal model will be studied. |
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Keywords: | Simulated moving bed chromatography Continuous separation processes Preparative chromatography Carbohydrates |
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