| ent-贝壳杉烷型二萜化合物的细胞毒活性研究进展 |
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| 引用本文： | 张大永,李子元,施连勇,吴晓明,华维一.ent-贝壳杉烷型二萜化合物的细胞毒活性研究进展[J].有机化学,2008,28(11):1911-1917. |
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| 作者姓名： | 张大永 李子元 施连勇 吴晓明 华维一 |
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| 作者单位： | 中国约科大学药学院,南京,210009 |
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| 摘 要： | 详细地概述了各类天然与合成的ent-贝壳杉烷二萜化合物的细胞毒活性研究进展, 总结和讨论了这类化合物的构效关系、作用机制以及对多种人癌细胞系的选择性, 评述了这类化合物作为抗肿瘤药物的开发潜力, 提出了目前存在的问题与不足, 并对其发展前景和研究方向做出了预测和展望.
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| 关 键 词： | ent-贝壳杉烷二萜化合物 细胞毒活性 构效关系 作用机制 肿瘤细胞系选择性 |
| 收稿时间： | 2007-11-20 |
| 修稿时间： | 2008-4-14 |
Advances in Research on Cytotoxinic Activity of ent-Kaurane Diterpenoids |
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| ZHANG,Da-Yong,LI,Zi-Yuan,SHI,Lian-Yong,WU,Xiao-Ming,HUA,Wei-Yi.Advances in Research on Cytotoxinic Activity of ent-Kaurane Diterpenoids[J].Chinese Journal of Organic Chemistry,2008,28(11):1911-1917. |
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| Authors: | ZHANG Da-Yong LI Zi-Yuan SHI Lian-Yong WU Xiao-Ming HUA Wei-Yi |
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| Institution: | (School of Pharmacy, China Pharmaceutical University, Nanjing 210009) |
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| Abstract: | The recent progress in natural or synthetical ent-kaurane diterpenoids possessing definite cyto- toxinic activity is reviewed in detail, the structure-activity relationships, mechanisms and selectivities upon multiple human tumor cell lines are discussed, the potential for the development as prospective anti-tumor drugs is evaluated, some temporary problems are summarized, and the prospects of the development and the directions of the research are anticipated. |
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| Keywords: | ent-kaurane diterpenoid cytotoxinic activity structure-activity relationship mechanism selec- tivity to tumor cell line |
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