Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis |
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| Authors: | Giner José-Luis Rocchetti Stefano Neunlist Serge Rohmer Michel Arigoni Duilio |
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| Affiliation: | Laboratorium für Organische Chemie, ETH-H?nggerberg HCI H307, CH-8093, Zürich, Switzerland. |
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| Abstract: | Incubation of samples of 2,3-dihydrosqualene, specifically labeled with deuterium at either carbon position 7 or 11, with an enzyme extract from Tetrahymena pyriformis, containing a squalene-tetrahymanol cyclase, provided specimens of euph-7-enes displaying deuterium patterns consistent with the biosynthetic operation of two consecutive 1,2-hydride shifts. |
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