Synthesis and antimicrobial activities of some isocoumarin and dihydroisocoumarin derivatives |
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Authors: | Hussain M Hussain Muhammad T Rama Nasim H Hameed S Malik A Khan Khalid M |
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Affiliation: | Department of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan. |
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Abstract: | A new series of the isocoumarin derivatives of ibuprofen, fluribiprofen, naproxen, valproic acid and 1-naphthoic acid have been synthesized via condensation of homophthalic acid with their respective acid chlorides. The conversion of the latter two isocoumarins into (dl)-3,4-dihydroisocoumarins has also been achieved. Most of the synthesized compounds showed antifungal and antibacterial activities. |
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