Resolution of naftopidil and bufuralol enantiomers by high-performance liquid chromatography on cellulose tris-(3,5-dimethylphenyl carbamate) column |
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| Authors: | Hassan Y. Aboul-Enein Vince Serignese |
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| Affiliation: | (1) Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211 Riyadh, Saudi Arabia |
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| Abstract: | The liquid Chromatographic resolution of the racemic cardiovascular drugs naftopidil and bufuralol to their corresponding enantiomers was achieved on cellulose tris-(3,5-dimethylphenyl carbamate) chiral stationary phase known as Chiralcel OD. The chiral recognition mechanism(s) involved between the chiral stationary phase and these drugs, which include hydrogen bonding, intercalative interactions, and steric interactions, among other factors, were discussed. |
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| Keywords: | naftopidil bufuralol enantiomer separation cellulose tris-(3,5-dimethylphenyl carbamate) chiral stationary phase chiral recognition mechanism(s) cellulose carbamates |
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