Distinct reactivity of Pd(OTs)2: the intermolecular Pd(II)-catalyzed 1,2-carboamination of dienes |
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| Authors: | Houlden Chris E Bailey Chris D Ford J Gair Gagné Michel R Lloyd-Jones Guy C Booker-Milburn Kevin I |
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| Affiliation: | School of Chemistry, Cantock's Close, University of Bristol, Bristol, BS8 1TS, UK. |
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| Abstract: | A Pd-catalyzed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ generation, or preformation, of a palladium tosylate emerges as a key parameter in gaining the requisite reactivity for the C-H insertion/carbopalladation/nucleophilic displacement process. |
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