Telaprevir fragments as organocatalysts in asymmetric direct aldol reactions of aldehydes |
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| Authors: | Chen Chen Weng Xinliang Xu Xiao Xia Xiong Xiu Lian Lu Yi Feng Zhou |
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| Affiliation: | 1. Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Xiasha, Hangzhou, Zhejiang, 310018, P. R. China
2. Zhejiang Apeloa Medical Tehnology Co. Ltd., Dongyang, Zhejiang, 322118, P. R. China
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| Abstract: | We have demonstrated that the fragments of Telaprevir can act as organocatalysts for asymmetric aldol reactions between aromatic aldehydes and acetone under mild conditions. The reaction conditions have been optimized in terms of the catalyst nature, choice of temperature, solvent, additive, and the catalyst loading. Under proper conditions, fairly good yield and enantioselectivity have been achieved. |
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