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Synthesis and spectroscopic characterization of indomethacin-Cd(II), Ce(III), and Th(IV) complexes: IR, 1H NMR,thermal, and biological studies |
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| Authors: | Moamen S Refat Gehad G Mohamed Mohamed Y S Ibrahim Hamada M A Killa Hammad Fetooh |
| Institution: | 1. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt 2. Department of Chemistry, Faculty of Science, Taif University, 888, Taif, Kingdom Saudi Arabia 3. Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt 4. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt |
| Abstract: | Solid complexes have been prepared and characterized by IR, UV-Vis, elemental analysis, and 1H NMR. Indomethacin forms complexes with Cd(II), Ce(III), and Th(IV) ions in molar ratios (ligand: metal) (2: 1), (3: 1), and (4: 1), respectively. The IR spectra of the complexes suggest that the Indomethacin behaves as a monobasic monodentate ligand coordinated to the metal ions via the deprotonated carboxylate group. Prepared complexes exhibit higher antimicrobial activity against several microorganisms, compared to free ligand. |
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