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Synthesis of several new lanthanide Glimepiride complexes for evaluation of microbial activity |
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| Authors: | M G Abd El-Wahed Samy M El-Megharbel Mohamed Y El-Sayed Yasmin M Zahran Moamen S Refat |
| Institution: | 1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt 2. Department of Chemistry, Faculty of Science, Taif University, 888, Taif, Kingdom Saudi Arabia 3. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Port Said, Egypt |
| Abstract: | The complexation between lanthanide metal ions like Nd(III), Tb(III), and Er(III) with Glimepiride produces 1: 1 molar ratio (metal: Glimepiride) monodentate complexes of general formula: M(GMP)(H2O)4]Cl3·xH2O, where: M = Nd, Tb, and Er, x = 1, 10, respectively. The structures of obtained compounds were assigned by IR, 1H NMR and UV/Vis spectra. Themogravimetric analysis and kinetic thermodynamic parameters have proved the thermal stability of Glimepiride complexes. Obtained lanthanide complexes showed significant effect against some bacteria and fungi. |
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