Compounds with antiproliferative activity on five human cancer cell lines from South Korean Carpesium triste |
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| Authors: | Moon Hyung-In |
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| Institution: | Department of Medicinal Biotechnology, College of Natural Resources and Life Science, Dong-A University, Busan, South Korea. himun68@dau.ac.kr |
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| Abstract: | In the search for antiproliferative compounds against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), it was found that the chloroform extracts obtained from the whole plant of Carpesium rosulatum Miq. (Compositae) exhibited significant cytotoxic activity. Two sesquiterpene lactones, CT-1 (2alpha,5-epoxy-5,10-dihydroxy-6-angeloyloxy-9beta-isobutyloxy-germacran-8alpha, 12-olide), and CT-2 (2beta,5-epoxy-5,10-dihydroxy-6alpha,9beta-diangeloyloxy-germacran-8alpha,12-olide) were isolated from the whole plant. CT-2 showed the most potent cytotoxicity with an IC50 value of 7.88 microM against SK-MEL-2. |
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