Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. japonicum |
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Authors: | Min B S Gao J J Nakamura N Kim Y H Hattori M |
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Institution: | Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan. |
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Abstract: | A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var. japonicum, together with pratorimine (2), lycorine (3) and 4'-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4,5-etheno-9,10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells. |
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