Polymeric micelles and nanoparticles from block and statistical poly((RS)-3,3-dimethylmalic acid) derivatives: preparation and characterization |
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Authors: | Ouhib Farid Randriamahefa Solo Wintgens Véronique Guérin Philippe Barbaud Christel |
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Institution: | Laboratoire de Recherche sur les Polyméres, UMR C7581 CNRS-Université Paris XII, 2-8 Rue Henri Dunant, F-94320 Thiais, France. |
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Abstract: | Amphiphilic and biodegradable micelles and nanoparticles designed as potential drug carriers were prepared from biodegradable statistical and block copolyesters obtained by a living anionic ring-opening process. These novel materials display amphiphilic properties arising from the joint presence of hydrophilic poly((RS)-3,3-dimethylmalic acid) and hydrophobic poly(hexyl (RS)-3,3-dimethylmalate) segments. Micelles obtained from a well-defined block copolymer have been characterized by their critical aggregation concentration, and nanoparticles derived from statistical copolymer have been analyzed by transmission electron microscopy (TEM). |
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Keywords: | amphiphilic copolyesters block copolymers micelles nanoparticles statistical copolymers |
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