组氨酸和五乙烯六胺功能化掺硼石墨烯量子点的合成及荧光检测中草药中姜黄素

Citric acid,histidine,pentaethylenehexamine and boric acid were mixed and pyrolyzed to prepare histidine and pentaethylenehexamine-functionalized and boron-doped graphene quantum dots （HPB-GQD）. The resulting HPB-GQD was composed of graphene sheets with size of 4.17±0.12 nm, and also with rich functional groups at the edges of graphene sheets. The fluorescence emission of HPB-GQD depended on the excitation wavelength. Ultraviolet excitation at 375 nm produced the strongest blue fluorescence emission. The fluorescence quantum yield was 87.4%, which was significantly better than that of traditional GQD,and single histidine, pentaethylenehexamine or boric acid-functionalized GQD,showing that introduction of histidine, pentaethylenehexamine and boron can significantly improve the luminescence efficiency. Based on the fluorescence quenching by the interaction between curcumin and HPB-GQD, a method for fluorescence determination of curcumin was established. The linear range and detection limit were 0.05-20.0 μmol/L and 0.017 μmol/L,respectively. The proposed method has been successfully applied to the fluorescence detection of curcumin in Chinese herbal medicine. The results were basically consistent with those of liquud chromatographymass spectrometry（LC-MS）and the recoveries were in the range of 96.0%-104.0%. © 2023 The Authors.

Synthesis of histidine and pentaethylenehexamine-functionalized and borondoped graphene quantum dots and its application in fluorescence detection of curcumin in Chinese herbal medicine