Research progress in mass spectrometry analysis for samples containing non-volatile saltsEI北大核心CSCD

It’s still a challenge for mass spectrometers （MS） to analyze samples in non-volatile salts systems. On the one hand, non-volatile salts are easy to crystallize, which will seriously contaminate and clog the transmission system of mass spectrometry, such as capillaries, ion transfer tubes, sampling cones, etc., thus the analysis results can be affected and the MS can be damaged. On the other hand, non-volatile salts always bring ion suppression, which significantly reduces the signal intensity of the analytes. At the same time, the mass spectrum will be dominated by a large number of salt cluster peaks, interfering with the discrimination of charge state. Recently, different methods have been developed to solve above two problems. This article reviewed the present research progress of mass spectrometry analysis for salt-containing samples, focusing on the role of conventional ion source modification and ambientionization mass spectrometry in the analysis of salt-containing samples. Pretreatment methods were also summarized briefly. Finally, the development tendency of mass spectrometry analysis for salt containing samples is predicted and prospected. © 2023, Youke Publishing Co.,Ltd. All rights reserved.