In vitro PHOTODYNAMIC INACTIVATION OF Herpes simplex VIRUS WITH SAPPHYRINS: 22 π-ELECTRON PORPHYRIN-LIKE MACROCYCLES |
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| Authors: | M. M. JUDY J. L. MAITHEWS J. T. NEWMAN H. L. SKILES R. L. BORIACK J. L. SESSLER M. CYR B. G. MAIYA S. T. NICHOL |
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| Affiliation: | Baylor Research Foundation, Baylor University Medical Center, Dallas, TX 75226. |
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| Abstract: | The photodynamic inactivation of HSV-1, a virus having a membranous envelope, with both a decaalkyl sapphyrin and its dicarboxy-substituted analog was studied. The decaalkyl sapphyrin was as efficient in the inactivation of HSV-1 on a per macrocycle basis as DHE, whereas the efficiency of the dicarboxy-substituted sapphyrin was approximately two orders of magnitude less. Fluorescence studies of sapphyrin's binding to liposomes and VSV suggested that the decaalkylsapphyrin bound monomerically to cholesterol-rich regions of the viral envelope, whereas its charged analog localized in a more polar environment. |
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