|
|||||
|
|
Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence |
|
| Authors: | Jay Jin Saranya Kittanakom Victoria Wong Beverly AS Reyes Elisabeth J Van Bockstaele Igor Stagljar Wade Berrettini Robert Levenson |
| Affiliation: | (1) Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA;(2) Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry and Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada;(3) Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA;(4) Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA |
| Abstract: | BackgroundOpioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). Opioid agonists appear to alter neuronal morphology in key brain regions implicated in the development of opioid dependence. However, the precise role of the MOR in the development of these neuronal alterations remains elusive. We hypothesize that identifying and characterizing novel MOR interacting proteins (MORIPs) may help to elucidate the underlying mechanisms involved in the development of opioid dependence. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |