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Synthesis and antitumor activity of puupehedione and related compounds |
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| Authors: | Alejandro F Barrero Enrique J Alvarez-Manzaneda Rachid Chahboun M Corts V Armstrong |
| Institution: | a Departamento de Química Orgánica. Facultad de Ciencias, Universidad de Granada, 18071, Granada, Spain b Departamento at Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Correo 22, Santiago, Chile |
| Abstract: | The first enantiospecific synthesis of bioactive marine puupehedione (2) and related compounds from (−)-sclareol (11) is reported. The antitumor activity of these compounds was assayed and compared with that of the natural products. |
| Keywords: | Terpenes antitumour compounds marine metabolites |
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