Functional and highly porous scaffolds for biomedical applications |
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Authors: | Tyson Therese Målberg Sofia Wåtz Veronica Finne-Wistrand Anna Albertsson Ann-Christine |
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Affiliation: | Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, SE-100 44, Stockholm, Sweden. |
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Abstract: | Highly porous functional scaffolds were obtained from linear and cross-linked multifunctional poly(ε-caprolactone) and poly(L-lactide). The polymers were synthesized by ring-opening polymerization of ε-caprolactone and L-lactide using poly(but-2-ene-1,4-diyl malonate) (PBM) as macroinitiator and stannous 2-ethylhexanoate. The presence of a double bond in each repeating unit of PBM enabled cross-linking of both scaffolds and films. Soft and flexible scaffolds were created from cross-linked PBM. The mechanical properties of scaffolds and films were evaluated under cyclic conditions, with a focus on the compositions and molecular weights. It was obvious that PBM in the polymers and its cross-linking ability resulted in tunable material characteristics, including an increased ability to recover after repeated loading. |
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Keywords: | functionalization of polymers porous scaffolds ring‐opening polymerization tissue engineering |
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