Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of Hedgehog signaling based on cyclopamine |
| |
| Authors: | Zhang Zhihui Baubet Valérie Ventocilla Christian Xiang Chaomei Dahmane Nadia Winkler Jeffrey D |
| |
| Institution: | Department of Chemistry, The University of Pennsylvania , Philadelphia, Pennsylvania 19104, USA. |
| |
| Abstract: | Previous work in this laboratory established that the readily available F-ring aromatic analog of cyclopamine is a highly potent inhibitor of Hedgehog signaling. The synthesis and biological evaluation of two F-ring saturated analogs that are more potent than the F-ring aromatic structure are reported. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
