Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert-butyl thiol linker |
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Authors: | Raz Richard Rademann Jörg |
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Institution: | Leibniz Institute of Molecular Pharmacology (FMP), 13125, Germany. |
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Abstract: | tert-Butyl thioesters display an astonishing stability toward secondary amines in basic milieu, in contrast to other alkyl and aryl thioesters. Exploiting this enhanced stability, peptide thioesters were synthesized in a direct manner, applying a tert-butyl thiol linker for Fmoc-based solid-phase peptide synthesis. |
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