Chiral Zn-catalyzed aerobic oxidative kinetic resolution of α-hydroxy ketones |
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Authors: | Pandi Muthupandi Govindasamy Sekar |
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Affiliation: | a Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, Tamil Nadu, India |
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Abstract: | The aerobic oxidative kinetic resolution of racemic α-hydroxy ketones was accomplished using a chiral Zn-quinine complex as the catalyst in the presence of molecular oxygen. The resulting optimized reaction conditions were applied to resolute different types of racemic α-hydroxy ketones and a maximum of 9.2 selectivity (s) was obtained with 88% ee for the recovered α-hydroxy ketone. |
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