Studies on the exchange of gramicidin in liposomes |
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| Authors: | G Jyothi Chanchal K Mitra G Krishnamoorthy |
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| Institution: | School of Life Sciences, University of Hyderabad, Hyderabad - 500 134 India;Chemical Physics Group, Tata Institute of Fundamental Research, Bombay - 400 005 India |
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| Abstract: | The exchange of gramicidin between liposomes made of two different kinds of phospholipids has been studied using a fluorescent probe (pyranine). The experimentally observed rate of exchange is compared with that of nigericin, which is a simple carrier. Possible reasons for the difference in the rate of exchange are discussed and probable mechanisms suggested. It is proposed that gramicidin exchanges between vesicles by a contact mechanism. |
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