Oxone/CaCl2/TEMPO体系在温和条件下对醇的氧化反应 |
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引用本文: | 陶晓春,余伟,张钧陶. Oxone/CaCl2/TEMPO体系在温和条件下对醇的氧化反应[J]. 有机化学, 2010, 30(2): 250-253 |
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作者姓名: | 陶晓春 余伟 张钧陶 |
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作者单位: | (华东理工大学金属有机化学研究室 上海 200237) (SH-Icon, Inc., 118 Peace Avenue, Bolingbrook, IL 60490, USA) |
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摘 要: | Oxone/TEMPO/CaCl2 (TEMPO=2,2,6,6-Tetramethyl-1-piperidinyloxy)是一种稳定安全和易得的氧化催化体系, 在室温条件下, 可以氧化苄基或烷基醇生成醛或酮. 苄基伯醇很容易被氧化成相应的醛, 有较高的反应收率(90%~96%), 仲醇氧化成相应的酮, 收率在81%~85%之间, 1,4-丁二醇环氧化生成γ-丁内酯得到了94%的收率.
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关 键 词: | Oxone 醇 CaCl2 TEMPO 氧化 |
收稿时间: | 2009-05-15 |
修稿时间: | 2009-07-04 |
Oxidation of Alcohols under Mild Conditions Using Oxone/CaCl2/TEMPO |
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Affiliation: | (Laboratory of Organometallic Chemistry, East China University of Science and Technology, Shanghai 200237) (SH-Icon, Inc., 118 Peace Avenue, Bolingbrook, IL 60490, USA) |
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Abstract: | An efficient catalytic oxidization using a stable and safe oxone/CaCl2/TEMPO (TEMPO=2,2,6,6-Tetramethyl-1-piperidinyloxy) system to convert alkyl or benzyl alcohols to carbonyl compounds under room temperature is described. Primary benzyl alcohols are readily oxidized to the corresponding aldehydes in excellent yields (90%~96%). Secondary alcohols are converted to corresponding ketones in 81%~85% yields. Oxidative cyclization of 1,4-diol to γ-lactone in 94% is obtained. |
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Keywords: | oxone alcohol calcium chloride TEMPO oxidation |
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