Synthesis and some properties of 4-oxo-3,4-dihydro- and 2,4-dioxo-1,2,3,4-tetrahydropyrimido[5,4-b]indoles

The condensation of N-(2-ethoxycarbonylindol-3-yl)-N,N-dialkylamidines with ammonia, primary amines, and hydrazines has given a series of 4-oxopyrimido5,4-b] indoles which have been converted into the 4-chloro and then into the 4-methoxy, 4-dialkylamino, and 4-mercapto derivatives. 2,4-Dioxopyrimido5,4-b]indoles have been synthesized by the successive action of chloroformic ester and then methylamine, hydrazine, or ethylhydrazine on 3-amino-2-ethoxycarbonylindoles differing by their substituents in position 5.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 635–639, May, 1985.