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New heterocyclic systems based on 1-hydrazino-5,6,7,8-tetrahydro[2,7]naphthyridine: 7,8,9,10-tetra-hydro[1,2,4]triazolo[3,4-a]- and 7,8,9,10-tetra-hydro[1,2,4]triazolo[5,1-a][2,7]naphthyridines
Authors:S N Sirakanyan  N G Avetisyan  A S Noravyan
Institution:1. The Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Sciences of the Republic of Armenia, A. L. Mnjoyan Institute of Fine Organic Chemistry, 6 Azatutyan Ave., Yerevan, 0014, Armenia
Abstract:Methods have been developed for the synthesis of new substituted 7,8,9,10-tetrahydro1,2,4]triazolo-3,4-a]2,7]naphthyridines from 3-chloro-1-hydrazino-7-methyl-5,6,7,8-tetrahydro-2,7]naphthyridine-4-carbonitrile. It was shown that on heating in an amine (ethanolamine, pyrrolidine, 2-hydroxy-propylamine), they undergo a Dimroth rearrangement at the triazole fragment, being converted into 7,8,9,10-tetrahydro1,2,4]triazolo5,1-a]2,7]naphthyridine derivatives.
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