Study on inclusion interaction of piroxicam with beta-cyclodextrin derivatives |
| |
Authors: | Xiliang Guo Yu Yang Guoyan Zhao Guomei Zhang Jianbin Chao Shaomin Shuang |
| |
Institution: | Department of Chemistry, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China. |
| |
Abstract: | The inclusion behavior of piroxicam (PX) with beta-cyclodextrin (beta-CD), hydroxypropyl-beta-cyclodextrin (HP-beta-CD), and carboxymethyl-beta-cyclodextrin (CM-beta-CD) was investigated by using steady-state fluorescence and nuclear magnetic resonance (NMR) technique. The various factors affecting the inclusion process were examined in detail. The remarkable fluorescence emission enhancement upon addition of CDs suggested that cyclodextrins (CDs) were most suitable for inclusion of the uncharged species of PX. The stoichiometry of the PX-CDs inclusion complexes was 1:1, except for beta-CD where a 1:2 inclusion complex was formed. The formation constants showed the strongest inclusion capacity of beta-CD. NMR showed the inclusion mode of PX with CDs. |
| |
Keywords: | Piroxicam Cyclodextrin Steady-state fluorescence Nuclear magnetic resonance (NMR) |
本文献已被 ScienceDirect PubMed 等数据库收录! |