Pigment epithelium-derived factor protects retinal ganglion cells |
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Authors: | Iok-Hou Pang Hong Zeng Debra L Fleenor Abbot F Clark |
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Institution: | (1) Alcon Research, Ltd. 6201 South Freeway, R3-24, Fort Worth, 76134 TX, USA |
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Abstract: | Background Retinal ganglion cells (RGCs) are responsible for the transmission of visual signals to the brain. Progressive death of RGCs
occurs in glaucoma and several other retinal diseases, which can lead to visual impairment and blindness. Pigment epithelium-derived
factor (PEDF) is a potent antiangiogenic, neurotrophic and neuroprotective protein that can protect neurons from a variety
of pathologic insults. We tested the effects of PEDF on the survival of cultured adult rat RGCs in the presence of glaucoma-like
insults, including cytotoxicity induced by glutamate or withdrawal of trophic factors. |
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