Microcalorimetric study of the effect of porphyrin-cholesterol esters on cancer cells HL-60 |
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| Authors: | Liu Yi Xie Changli Huang Suqiu Qu Songsheng Wang Jun Yang Yuzhen |
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| Institution: | (1) Department of Chemistry, Wuhan University, 430072 Wuhan, China;(2) Department of Chemistry, Department of Medical Molecular Biology, Tongji Medical University, 430030 Wuhan, China |
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| Abstract: | By using an LKB-2277 Bioactivity Monitor, the effect of porphyrin-cholesterol esters on cancer cells HL-60 were examined at
25°C. There is a difference in the shape of the thermogenesis curve samong different kinds of porphyrin-cholesterol esters,
and the death rate of HL-60 cells is also different. The results show that porphyrin-chsterol esters can powerfully inhibit
their metabolism, the inhibitory sequence is II>I>III, but the inhibitory way of each ester is different.
Supported by the National Natural Science Foundation of China
Liu Yi: born in Nov. 1970, Ph. D. graduate student |
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| Keywords: | Porphyrin-cholesterol ester Cancer cells HL-60 Microcalorimetric method Thermochemistry |
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