Syntheses of 6-sulfo sialyl Lewis X glycans corresponding to the L-selectin ligand "sulfoadhesin" |
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Authors: | Pratt Matthew R Bertozzi Carolyn R |
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Affiliation: | Thios Pharmaceuticals, 5980 Horton Suite 400, Emeryville, California 94608, USA. mattrpratt@yahoo.com |
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Abstract: | [structure: see text] Divergent syntheses of sulfated sialyl Lewis X oligosaccharides corresponding to the core 1 and core 6 branches of the L-selectin ligand are reported. These synthetic targets incorporate a selectively protected serine residue at the reducing terminus, providing a functional handle for further conjugation. |
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