| Synthesis and Crystal Structure of 4-（4-Chlorophenyl）-6-methyl-5-methoxy-caronyl-3,4-dihydropyrimidin-2（H）-one |
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| 引用本文： | 华国平,屠树江,房芳,屠蔓苏,史达清,王香善,纪顺俊,张勇.Synthesis and Crystal Structure of 4-（4-Chlorophenyl）-6-methyl-5-methoxy-caronyl-3,4-dihydropyrimidin-2（H）-one[J].结构化学,2004,23(11):1295-1299. |
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| 作者姓名： | 华国平 屠树江 房芳 屠蔓苏 史达清 王香善 纪顺俊 张勇 |
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| 作者单位： | HUA Guo-Pinga TU Shu-Jiang b② FANG Fanga TU Man-Sua SHI Da-Qingb WANG Xiang-Shanb a (Xuzhou Institute of Architectural Technology，Xuzhou，Jiangsu 221008，China) b (Department of Chemistry，Xuzhou Normal University; Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province，Xuzhou，Jiangsu 221009，China) JI Shun-Jun ZHANG Yong (College of Chemistry and Chemical Engineering，Key Lab of Organic Synthesis of Jiangsu Province，Suzhou University，Jiangsu 215006，China) |
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| 基金项目： | This work was supported by the NNSFC (No. 20372057)，Natural Science Foundation of Jiangsu Province (No. BK2001142)，the Open Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province，College of Chemistry and Chemical Engineering，Su |
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| 摘 要： | 1 INTRODUCTION Biginelli reaction is a three-component condensa-tion of ethyl acetoacetate, benzaldehyde and urea forthe synthesis of 3,4-dihydropyrimidin-2(1H)-ones(Scheme 1). The reaction can be carried out in aone-pot fashion in alcohol solution in t…
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| 关 键 词： | 合成 晶体结构 4-（4-氯苯）-6-甲基-5-甲氧基-蒈酮-3，4-二氢嘧啶-2（H）-酮 微波辐射 溴酸 |
Synthesis and Crystal Structure of 4-(4-Chlorophenyl)-6-methyl-5-methoxy-caronyl-3,4-dihydropyrimidin-2(H)-one |
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| Institution: | Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu 221008, China;Department of Chemistry, Xuzhou Normal University; Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou, Jiangsu 221009, China;College of Chemistry and Chemical Engineering, Key Lab of Organic Synthesis of Jiangsu Province, Suzhou University, Jiangsu 215006, China |
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| Abstract: | The title compound 4-(4-chlorophenyl)-6-methyl-5-methoxy-caronyl-3,4-dihydro- pyrimidin-2(H)-one has been synthesized by the reaction of 4-chlorobenzaldehyde, methyl acetoa- cetate and urea using H3BO3 as a catalyst under microwave irradiation. Its structure was charac- terized by X-ray single-crystal diffraction techniques with the following data: triclinic, space group P, a = 5.4513(4), b = 7.619(1), c = 16.118(4) A, α= 80.42(1),β= 83.43(1),γ= 79.29(1)0, V = 646.1919 A3, Mr = 280.70, μ(MoKα) = 0.301 mm-1, Z = 2 and Dc = 1.443 g/cm3. In the molecule the pyrimidine ring is of boat conformation. |
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| Keywords: | microwave irradiation 3 4-dihydropyrimidinone H3BO3 crystal structure |
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