Mechanoenzymatic resolution of racemic chiral amines,a green technique for the synthesis of pharmaceutical building blocks |
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Authors: | Mario Pérez-Venegas Eusebio Juaristi |
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Affiliation: | 1. Departamento de Química, Centro de Investigación y de Estudios Avanzados, Av. IPN 2508, 07360, Ciudad de México, Mexico;2. El Colegio Nacional, Luis Gonzáles Obregón 23, Centro Histórico, 06020, Ciudad de México, Mexico |
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Abstract: | Very recently, several successful biocatalytic processes using mechanical activation to carry out enantioselective reactions have been reported. The present work describes the use of Candida antarctica Lipase B (CALB) in the kinetic resolution of racemic chiral amines by means of High-Speed Ball Milling (HSBM), minimizing the use of solvent and reducing reaction times. This approach provides an efficient and easily scalable strategy that was used for the green synthesis of enantiopure Rasagiline, as an illustrative example. |
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Keywords: | Mechanochemistry Kinetic resolution CALB Rasagiline Green chemistry |
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