Unexpected acetylcholinesterase activity of cocaine esterases |
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| Authors: | Rogers Claude J Eubanks Lisa M Dickerson Tobin J Janda Kim D |
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| Affiliation: | Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
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| Abstract: | A series of proteins with cocaine esterase ability have been shown to hydrolyze acetylcholine with similar rate enhancements. Docking studies revealed that acetylcholine binds in a similar orientation as cocaine. These results suggest that acetylcholinesterase activity may be inherent to cocaine esterases. |
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