A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity |
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| Authors: | Zhao Yongmei He Weijiang Shi Pengfei Zhu Jianhui Qiu Lin Lin Liping Guo Zijian |
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| Institution: | State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P R China. |
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| Abstract: | A trinuclear 3N-chelated monofunctional platinum complex, Pt3(HPTAB)Cl3](ClO4)3 (HPTAB = N,N,N',N',N',N'-hexakis(2-pyridylmethyl)-1,3,5-tris(aminomethyl)benzene), has been structurally characterized, which binds to DNA and demonstrates much higher potency against the murine leukemia cell line (P-388) and the human nonsmall-cell lung cancer cell line (A-549) than cisplatin. |
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