| 香豆素衍生物荧光传感器对Zn2+的识别及细胞成像 |
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| 引用本文： | 尹计秋,安永林,贾献超,焦扬.香豆素衍生物荧光传感器对Zn2+的识别及细胞成像[J].无机化学学报,2022,38(2):368-376. |
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| 作者姓名： | 尹计秋 安永林 贾献超 焦扬 |
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| 作者单位： | 大连理工大学精细化工国家重点实验室;大连医科大学检验医学院 |
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| 基金项目： | 大连市高层次人才创新支持计划(No.2019RQ039);中央高校基本科研业务费专项资金(No.DUT20LK12)资助。 |
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| 摘 要： | 制备了基于香豆素衍生物的荧光传感器CANQ,其可选择性地识别Zn2+离子。通过NMR、MS、荧光光谱等技术研究了传感器的结构及荧光性能。传感器CANQ对Zn2+离子具有显著的荧光增强响应,且响应速度快、选择性高、生物相容性好,可用于MCF?7细胞中Zn2+离子的成像。
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| 关 键 词： | Zn2+离子 香豆素衍生物 荧光传感器 识别 |
| 收稿时间： | 2021/7/30 0:00:00 |
| 修稿时间： | 2021/11/17 0:00:00 |
Recognition and Cell Imaging of Zn2+ by Coumarin Derivative Fluorescence Sensor |
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| YIN Ji-Qiu,AN Yong-Lin,JIA Xian-Chao,JIAO Yang.Recognition and Cell Imaging of Zn2+ by Coumarin Derivative Fluorescence Sensor[J].Chinese Journal of Inorganic Chemistry,2022,38(2):368-376. |
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| Authors: | YIN Ji-Qiu AN Yong-Lin JIA Xian-Chao JIAO Yang |
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| Institution: | (State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian,Liaoning 116024,China;College of Medical Laboratory,Dalian Medical University,Dalian,Liaoning 116044,China) |
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| Abstract: | Coumarin-derived fluorescence sensor was designed and synthesized to selectively recognize Zn2+ ions. The structure and fluorescence properties of the sensor were investigated by NMR, MS, fluorescence spectroscopy, and other technical methods. Sensor CANQ exhibited conspicuous fluorescent enhancement response to Zn2+ ion and had the characteristic of fast response, high selectivity, and good biocompatibility. It has been applied to the imaging of Zn2+ ions in MCF-7 cells. |
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| Keywords: | Zn2+ion coumarin derivative fluorescent sensor recognition |
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