| 药物中间体(S)-3-羟基四氢呋喃的合成研究 |
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| 引用本文： | 王晓琴,朱德荣,何明华. 药物中间体(S)-3-羟基四氢呋喃的合成研究[J]. 化学研究与应用, 2009, 21(7) |
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| 作者姓名： | 王晓琴 朱德荣 何明华 |
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| 作者单位： | 广东医学院药物化学与药分教研室,广东,东莞,523808;广东医学院药物化学与药分教研室,广东,东莞,523808;广东医学院药物化学与药分教研室,广东,东莞,523808 |
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| 摘 要： |
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| 关 键 词： | (S)-3-羟基四氢呋喃 合成 L-苹果酸 |
Study on synthesis of drug intermediates (S)-3-hydroxy-tetra hydrofuran |
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| WANG Xiao-qin,ZHU De-rong,HE Ming-hua. Study on synthesis of drug intermediates (S)-3-hydroxy-tetra hydrofuran[J]. Chemical Research and Application, 2009, 21(7) |
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| Authors: | WANG Xiao-qin ZHU De-rong HE Ming-hua |
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| Affiliation: | Dept.of Medicinal Chemisty and Pharm-analysis;Guangdong Medical University;Dongguan 523808;China |
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| Abstract: | (S)-3-hydroxy-tetrahydrofuran was synthesized from L-malic acid by esterification,reduction,cyclization.The chemical structures of the target compound was identified by element analysis,IR,NMR andMS spectra.The total yield and the purity of the product were 41% and 99.2%,the optical purity was 95.8%.This optimal synthetic procedure with lower cost and mild reaction conditions be worthy to have a further pilot manufacture. |
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| Keywords: | (S)-3-hydroxy-tetrahydrofuran synthesis L-malic acid |
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